DunedinPACNI: How a Brain Scan Predicts Dementia Risk and Measures Ageing

Sunday, 3 August 2025, 16:16

DunedinPACNI is a groundbreaking tool that utilizes brain scans to predict dementia risk and gauge biological ageing. This innovative research from Duke University, Harvard University, and the University of Otago leverages MRI technology to provide insights into a person's health trajectory. The Dunedin Study informs this tool, tracking individuals since birth and offering invaluable data on ageing processes over time.
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DunedinPACNI: How a Brain Scan Predicts Dementia Risk and Measures Ageing

Understanding DunedinPACNI and Its Impact on Dementia Risk

DunedinPACNI stands for Pace of Ageing Calculated from NeuroImaging. This innovative tool utilizes MRI scans to evaluate how quickly the human body is aging, with particular attention to predicting dementia risk. By focusing on the biological ageing process, researchers can ascertain potential health vulnerabilities long before any symptoms manifest.

How the Tool Works

Through the expertise of researchers from Duke University, Harvard University, and the University of Otago, DunedinPACNI provides a unique assessment based on a single brain scan. It measures the rate at which the brain and body age by monitoring molecular and cellular changes. This method stands apart from traditional ageing clocks that analyze data points from various ages at a given time.

Revolutionizing Dementia Prevention

DunedinPACNI not only predicts the risk of conditions such as frailty, heart attacks, and stroke, but it also serves as an early warning system for dementia. For individuals identified at risk, actionable lifestyle changes can potentially delay or prevent the onset of these chronic diseases.

The Future of Clinical Use

As researchers aim to develop reference charts for DunedinPACNI akin to those for BMI and height, the overall healthcare landscape may see a shift towards proactive health interventions. Understanding biological ageing through advanced neuroimaging could lead to earlier prevention strategies against serious health issues.


This article was prepared using information from open sources in accordance with the principles of Ethical Policy. The editorial team is not responsible for absolute accuracy, as it relies on data from the sources referenced.


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